Anti-TYW3 antibodies are used in the immunodetection of the protein tRNA-yW synthesizing protein 3 homolog. In humans, the canonical protein has a reported length of 259 amino acid residues and a mass of 29.8 kDa. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the caudate, vagina, and adrenal gland. A member of the TYW3 protein family, TYW3 is a suspected S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.
The TYW3 marker can be used to identify Type 2 Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase, tRNA-yW-synthesizing protein 3, and tRNA wybutosine-synthesizing protein 3 homolog. TYW3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some TYW3 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4