Anti-LIPE antibodies are used in the immunodetection of the protein lipase E, hormone sensitive type. In humans, the canonical protein has a reported length of 1076 amino acid residues and a mass of 116.6 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the testis. A member of the GDXG' lipolytic enzyme protein family, LIPE is known to be involved with cholesterol metabolism and homeostasis and the metabolism of lipids.
The LIPE marker can be used to identify Adipocytes.* Synonyms for this target antigen include FPLD6, HSL, LHS, REH, hormone-sensitive lipase, lipase, hormone-sensitive, monoacylglycerol lipase LIPE, and AOMS4. LIPE gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 930 citations in the literature describe the use of LIPE antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4