Anti-MSH6 antibodies are used in the immunodetection of the protein mutS homolog 6. In humans, the canonical protein has a reported length of 1360 amino acid residues and a mass of 152.8 kDa. Its subcellular localization is in the nucleus and chromosomes. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the DNA mismatch repair MutS protein family, MSH6 is a known component of the post-replicative DNA mismatch repair system (MMR). Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include GTMBP, HNPCC5, HSAP, LYNCH5, MMRCS3, p160, DNA mismatch repair protein Msh6, and GTBP. MSH6 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 100 citations in the literature describe the use of MSH6 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.