Anti-SQSTM1 antibodies are used in the immunodetection of the protein sequestosome 1. In humans, the canonical protein has a reported length of 440 amino acid residues and a mass of 47.7 kDa. Its subcellular localization is in the nucleus, cytoplasmic vesicles, ER, lysosomes and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. SQSTM1 is known to be an autophagy receptor required for selective macroautophagy (aggrephagy). Post-translational modifications have been described, including ubiquitination, protein cleavage and phosphorylation. The SQSTM1 gene has been associated with the disease, Paget disease of bone. Synonyms for this target antigen include A170 and DMRV. SQSTM1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.