Anti-NEDD8 antibodies are used in the immunodetection of the protein NEDD8 ubiquitin like modifier. In humans, the canonical protein has a reported length of 81 amino acid residues and a mass of 9.1 kDa. Its subcellular localization is in the nucleus. It is reported to be highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. A member of a the Ubiquitin protein family, NEDD8 is reported to be a ubiquitin-like protein, which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Post-translational modifications have been described, including protein cleavage. Synonyms for this target antigen include neural precursor cell expressed, developmentally down-regulated 8, ubiquitin-like protein Nedd8, and neddylin.