Anti-Prominin-1 antibodies are used for the immunodetection of the protein encoded by the PROM1 gene. In humans, the canonical protein has a reported length of 865 amino acid residues and a mass of 97.2 kDa. Its subcellular localization is in the ER and cell membrane. Alternative splicing is reported to yield 7 different isoforms for this protein. A member of the Prominin protein family, it is believed to play a role in cell differentiation, proliferation and apoptosis. Post-translational modifications have been described, including glycosylation and acetylation.
The prominin 1 marker can be used to characterize Hematopoietic Stem Cells (HSC), Cerebral Cortex MGE Interneurons, and Hepatic Progenitor Cells.* Other names for this target antigen include CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, and AC133. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 3500 citations in the literature describe the use of Prominin-1 antibodies in research. Flow Cytometry is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4