Anti-STIM2 antibodies are used in the immunodetection of the protein stromal interaction molecule 2. In humans, the canonical protein has a reported length of 746 amino acid residues and a mass of 84 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in all tissues and tumor cell lines examined. STIM2 is reported to play a role in in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Post-translational modifications have been described, including glycosylation and phosphorylation.