Anti-HLA-DMB antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DM beta. In humans, the canonical protein has a reported length of 263 amino acid residues and a mass of 28.9 kDa. Its subcellular localization is in the lysosomes. It is notably expressed in many tissues, such as the cerebellum, tonsil, and appendix. A member of the MHC class II protein family, HLA-DMB is known to play an important role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. Synonyms for this target antigen include RING7, HLA class II histocompatibility antigen, DM beta chain, MHC class II HLA-DMB, MHC class II antigen DMB, and D6S221E. HLA-DMB gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of HLA-DMB antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.