Anti-PLAT antibodies are used in the immunodetection of the protein plasminogen activator, tissue type. In humans, the canonical protein has a reported length of 562 amino acid residues and a mass of 62.9 kDa. It has been described to be a secreted protein. Up to 4 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the placenta and skin. A member of the Peptidase S1 protein family, PLAT is known to be involved with proteolysis.
The PLAT marker can be used to identify Glomerular Capillary Endothelial Cells.* Synonyms for this target antigen include TPA, tissue-type plasminogen activator, alteplase, plasminogen/activator kringle, reteplase, and T-PA. PLAT gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PLAT antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4