Anti-PRODH antibodies are used in the immunodetection of the protein proline dehydrogenase 1. In humans, the canonical protein has a reported length of 600 amino acid residues and a mass of 68 kDa. Its subcellular localization is in the mitochondria. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in the lung, skeletal muscle and brain, to a lesser extent in the heart and kidney, and weakly in the liver, placenta and pancreas. A member of the Proline oxidase protein family, PRODH is known to be involved with the response to oxidative stress.
The PRODH marker can be used to identify Proximal Tubule Segment 1 Epithelial Cells.* Synonyms for this target antigen include PIG6, POX, PRODH1, PRODH2, TP53I6, proline dehydrogenase 1, mitochondrial, p53-induced gene 6 protein, and HSPOX2. PRODH gene orthologs have been reported in the mouse, rat and chimpanzee species. A number of PRODH antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4