Anti-INSR antibodies are used in the immunodetection of the protein insulin receptor. In humans, the canonical protein has a reported length of 1382 amino acid residues and a mass of 156.3 kDa. Its subcellular localization is in the lysosomes and cell membrane. Up to 2 different isoforms have been reported for this protein. A member of the Tyr protein kinase protein family, INSR is a known receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Post-translational modifications have been described, including glycosylation and phosphorylation. The INSR gene has been associated with the disease, Rabson-Mendenhall syndrome. Synonyms for this target antigen include HHF5, IR, and CD220. INSR gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 1400 citations in the literature describe the use of INSR antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.