Anti-XIAP antibodies are used in the immunodetection of the protein X-linked inhibitor of apoptosis. In humans, the canonical protein has a reported length of 497 amino acid residues and a mass of 56.7 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be expressed in colonic crypts. A member of the IAP protein family, XIAP is reported to be a multi-functional protein, which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Synonyms for this target antigen include BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, and API3. XIAP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 320 citations in the literature describe the use of XIAP antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.