Anti-TH antibodies are used in the immunodetection of the protein tyrosine hydroxylase. In humans, the canonical protein has a reported length of 528 amino acid residues and a mass of 58.6 kDa. Its subcellular localization is in the nucleus, cytoplasmic vesicles, and cytoplasm. Up to 6 different isoforms have been reported for this protein. It is reported to be mainly expressed in the brain and adrenal glands. A member of the Biopterin-dependent aromatic amino acid hydroxylase protein family, Th is known to catalyze the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Synonyms for this target antigen include DYT5b, TYH, tyrosine 3-monooxygenase, dystonia 14, tyrosine 3-hydroxylase, and DYT14. TH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1900 citations in the literature describe the use of Th antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.