Anti-PDX1 antibodies are used in the immunodetection of the protein pancreatic and duodenal homeobox 1. In humans, the canonical protein has a reported length of 283 amino acid residues and a mass of 30.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably expressed in the rectum, pancreas, duodenum, colon, and appendix. A member of the Antp homeobox protein family, PDX1 is known to be involved with organ morphogenesis and nervous system development. Post-translational modifications have been described, including phosphorylation. The PDX1 marker can be used to identify Pancreatic Ductal Cells and Pancreatic Endocrine Cells.* Synonyms for this target antigen include IDX-1, IPF1, IUF1, MODY4, PAGEN1, STF-1, pancreas/duodenum homeobox protein 1, and GSF. PDX1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4