Anti-ITGAE antibodies are used in the immunodetection of the protein integrin subunit alpha E. In humans, the canonical protein has a reported length of 1179 amino acid residues and a mass of 130.2 kDa. Its subcellular localization is in the membrane. It is noted to be expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. A member of the Integrin alpha chain protein family, ITGAE is known to be involved with cell adhesion and cell matrix adhesion. Post-translational modifications have been described, including glycosylation.
The ITGAE marker can be used to identify Dendritic Cells, CD8+ Resident Memory T Cells, Type 1 Dendritic (DC) Cells, Type 2 Dendritic (DC2) Cells, and Monocyte-Derived Dendritic Cells.* Synonyms for this target antigen include HUMINAE, integrin alpha-E, HML-1 antigen, antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide, and CD103. ITGAE gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Over 1400 citations in the literature describe the use of ITGAE antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4