Anti-trinucleotide repeat containing adaptor 6B antibodies are used for the immunodetection of the protein encoded by the TNRC6B gene. In humans, the canonical protein has a reported length of 1833 amino acid residues and a mass of 194 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the GW182 protein family, it is reported to play a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). The gene encoding this protein is implicated in Global developmental delay with speech and behavioral abnormalities. Other names for this target antigen include trinucleotide repeat-containing gene 6B protein, trinucleotide repeat containing 6B, and GDSBA. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.