Anti-SRY-box transcription factor 10 antibodies are used for the immunodetection of the protein encoded by the SOX10 gene. In humans, the canonical protein has a reported length of 466 amino acid residues and a mass of 49.9 kDa. Its subcellular localization is in the membrane, nucleus, mitochondria, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in fetal brain and in adult brain, heart, small intestine and colon. It is reported to be a transcription factor that plays a central role in developing and mature glia (By similarity). The gene encoding this protein is implicated in Waardenburg syndrome 2E. Other names for this target antigen include PCWH, WS2E, WS4, WS4C, transcription factor SOX-10, SRY (sex determining region Y)-box 10, SRY-box 10, and DOM. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.