Anti-LIF receptor subunit alpha antibodies are used for the immunodetection of the protein encoded by the LIFR gene. In humans, the canonical protein has a reported length of 1097 amino acid residues and a mass of 123.7 kDa. Its subcellular localization is in the cell membrane and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Type I cytokine receptor protein family, it is known to be involved with receptor-mediated signaling pathways and cytokine-mediated signaling pathways. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Stuve-Wiedemann syndrome. Other names for this target antigen include SJS2, STWS, SWS, leukemia inhibitory factor receptor, CD118 antigen, and CD118. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.