Human LIFR alpha Antibody AF-249-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman LIFR alpha Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $539.00Supplier Page View Company Product Page
Catalog NumberAF-249-NA
NCBI Gene AliasesSJS2, SWS, CD118, LIF-R, STWS
ApplicationsELISA Development,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
Quantity250 ug (also 25 ug)
ReactivityHuman,Mouse
TargetLIFR alpha
IsotypeIgG
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
HostGoat
NCBI Full Gene NameLIF receptor subunit alpha
ClonalityPolyclonal
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human LIF R alpha, Gln45-Ser833, Accession # P42702
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and MigrationMediators of inflammationJanuary 1, 2023Chandrasekar B, Mummidi S, DeMarco VG, Higashi Y.CST), polyclonal human LIFR (used in neutralization (10 µg/ml) and western blotting (0.1 µg/ml)), #AF-249-NA, R&D Systems, Minneapolis, MN), and polyclonal antihuman gp130 (used in neutralization (2.5 µg/ml) and Western blotting

(2) Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in MiceInternational journal of molecular sciencesDecember 29, 2021Lörchner H, Adrian-Segarra JM, Waechter C, Wagner R, Góes ME, Brachmann N, Sreenivasan K, Wietelmann A, Günther S, Doll N, et al.

(3) Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy LossScientific reportsAugust 14, 2015Winship A, Correia J, Krishnan T, Menkhorst E, Cuman C, Zhang JG, Nicola NA, Dimitriadis E.diluted in 1 ×Tris-buffered saline (TBS) for 30 min. Primary antibody for LIFRα (1:100; R&D Systems #AF-249NA), LIF (1:100; R&D Systems #AF-250NA), phospho-STAT3 (Tyr705) (1:100; Cell Signaling Technologies #9145),

(4) The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in MedulloblastomaPloS oneJanuary 1, 2015Salm F, Dimitrova V, von Bueren AO, Ćwiek P, Rehrauer H, Djonov V, Anderle P, Arcaro A.to the indicated concentrations in cell culture medium just before use. The Anti-human LIFRα antibody (AF-249-NA) and the recombinant rh-LIF Rα (7487-LR) were purchased from R&D Systems (Minneapolis, MN, USA) and

(5) Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in MicePloS oneJanuary 1, 2015Winship A, Correia J, Zhang JG, Nicola NA, Dimitriadis E.diluted in 1×Tris-buffered saline (TBS) for 30min. Primary antibody for LIFRα (1:100; R&D Systems #AF-249NA), LIF (1:100; R&D Systems #AF250NA), pan-cytokeratin (1:200; Santa Cruz #H-240), α-SMA (1:200; Dako

(6) A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptorThe Journal of biological chemistrySeptember 21, 2012Chollangi S, Mather T, Rodgers KK, Ash JD.

(7) CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment EpitheliumPLoS ONESeptember 2, 2011Rong Li, Rong Wen, Tina Banzon, Arvydas Maminishkis, Sheldon S. Miller(Pierce Biotechnology) and probed with antibodies against CNTFRα (ab58560, Abcam, Cambridge, MA), LIFRβ (AF-249-NA, R & D Systems, Minneapolis, MN), gp130 (3732, Cell Signaling Technology, Danvers, MA), or OsMRβ (MAB4389,

(8) Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and micePloS oneJanuary 1, 2011Shuya LL, Menkhorst EM, Yap J, Li P, Lane N, Dimitriadis E.Tris-buffered saline [TBS]) for 1 hr at room temperature (RT) before the primary antibody (LIFRα, 2.5 µg/ml, #AF-249-NA R&D Systems) was applied for 1 h and incubated at RT. A non-immune goat IgG isotype control diluted

(9) Disturbances in the LIF pathway in the endometrium among women with unexplained infertilityFertility and sterilityJune 1, 2009Aghajanova L, Altmäe S, Bjuresten K, Hovatta O, Landgren BM, Stavreus-Evers A.

(10) Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cellsFertility and sterilityOctober 1, 2006Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O.

(11) Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injuryJournal of neuroimmunologyMay 1, 2006Pan W, Cain C, Yu Y, Kastin AJ.

(12) Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progressionCancer researchOctober 1, 2005Queen MM, Ryan RE, Holzer RG, Keller-Peck CR, Jorcyk CL.

(13) The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signalingFEBS lettersAugust 15, 2005He W, Gong K, Smith DK, Ip NY.

(14) Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill runningThe Journal of physiologyMay 1, 2004Malm C, Sjödin TL, Sjöberg B, Lenkei R, Renström P, Lundberg IE, Ekblom B.

(15) Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovariesMolecular human reproductionMay 1, 2004Abir R, Fisch B, Jin S, Barnnet M, Freimann S, Van den Hurk R, Feldberg D, Nitke S, Krissi H, Ao A.

(16) Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cellsThe Journal of clinical endocrinology and metabolismFebruary 1, 2003Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S.

(17) Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitroFEBS lettersMarch 13, 2002He W, Gong K, Zhu G, Smith DK, Ip NY.

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LIFR alpha Antibody

LIFR alpha Antibody

LIFR alpha Antibody

Human LIFR alpha Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (17)

Reviews

Human LIFR alpha Antibody from R&D Systems, a Bio-Techne Brand

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