Anti-GABRB2 antibodies are used in the immunodetection of the protein gamma-aminobutyric acid type A receptor subunit beta2. In humans, the canonical protein has a reported length of 512 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the cerebellum. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, GABRB2 is known to be involved with chemical synaptic transmission. Post-translational modifications have been described, including glycosylation.
The GABRB2 marker can be used to identify Dorsal Excitatory Neurons.* Synonyms for this target antigen include ICEE2, gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2, gamma-aminobutyric acid A receptor beta 2, gamma-aminobutyric acid type A receptor beta2 subunit, and DEE92. GABRB2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4