Anti-granulin precursor antibodies are used for the immunodetection of the protein encoded by the GRN gene. In humans, the canonical protein has a reported length of 593 amino acid residues and a mass of 63.5 kDa. Its subcellular localization is in the lysosomes and is secreted. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Granulin protein family, it is reported to be a secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Other names for this target antigen include GEP, GP88, PCDGF, PEPI, PGRN, progranulin, PC cell-derived growth factor, and CLN11. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 160 citations in the literature describe the use of granulin precursor antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.