Anti-IL3RA antibodies are used in the immunodetection of the protein interleukin 3 receptor subunit alpha. In humans, the canonical protein has a reported length of 378 amino acid residues and a mass of 43.3 kDa. Its subcellular localization is in the membrane. Up to 2 different isoforms have been reported for this protein. A member of the Type I cytokine receptor protein family, IL3RA is a reported cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Post-translational modifications have been described, including glycosylation.
The IL3RA marker can be used to identify Basophils, Dendritic Cells, Plasmacytoid Dendritic Cells, and Thymic Plasmacytoid Dendritic Cells.* Synonyms for this target antigen include IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, CD123 antigen, and CD123. IL3RA gene orthologs have been reported in the mouse and bovine species. Over 870 citations in the literature describe the use of IL3RA antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4