Anti-Tryptophan hydroxylase 2 antibodies are used for the immunodetection of the protein encoded by the TPH2 gene. In humans, the canonical protein has a reported length of 490 amino acid residues and a mass of 56.1 kDa. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to have brain specific expression. A member of the Biopterin-dependent aromatic amino acid hydroxylase protein family, it is known to be involved with metabolic processes.
The tryptophan hydroxylase 2 marker can be used to characterize Brain Splatter Neurons.* Other names for this target antigen include neuronal tryptophan hydroxylase, tryptophan 5-monooxygenase 2, and tryptophan 5-hydroxylase 2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 230 citations in the literature describe the use of Tryptophan hydroxylase 2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4