Anti-Uncoupling Protein 2 antibodies are used in the immunodetection of the protein encoded by the UCP2 gene. In humans, the canonical protein has a reported length of 309 amino acid residues and a mass of 33.2 kDa. Its subcellular localization is in the mitochondria. It is found to be widely expressed in adult human tissues, including tissues rich in macrophages. A member of the Mitochondrial carrier (TC 2.A.29) protein family, it is a reported antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Other names for this target antigen include SLC25A8, UCPH, dicarboxylate carrier SLC25A8, mitochondrial uncoupling protein 2, solute carrier family 25 member 8, and BMIQ4.