Anti-KRT7 antibodies are used in the immunodetection of the protein keratin 7. In humans, the canonical protein has a reported length of 469 amino acid residues and a mass of 51.4 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. It is a member of the Intermediate filament protein family. Post-translational modifications have been described, including methylation.
The KRT7 marker can be used to identify Sebum Secreting Cells, Eccrine Cells, Apocrine Cells, Cuboidal Cells, and Pancreatic Ductal Cells.* Synonyms for this target antigen include K2C7, K7, SCL, keratin, type II cytoskeletal 7, CK-7, cytokeratin 7, keratin 7, type II, and CK7. KRT7 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 800 citations in the literature describe the use of Krt7 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Flow Cytometry, Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4