Anti-Inhibitor of nuclear factor kappa-B kinase subunit beta antibodies are used in the immunodetection of the protein encoded by the IKBKB gene. In humans, the canonical protein has a reported length of 756 amino acid residues and a mass of 86.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. It is reported to be highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. A member of the Ser/Thr protein kinase protein family, it is reported to be a serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Post-translational modifications have been described, including ubiquitination, acetylation and phosphorylation. Other names for this target antigen include IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, I-kappa-B kinase 2, and IKK-beta.