IKKbeta (2C8) Rabbit mAb 2370S from Cell Signaling Technology

Product Specs
ItemIKKbeta (2C8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2370S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, M, R, Mk
TargetIKK-beta
HostRabbit
NCBI Gene AliasesIKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
ClonalityMonoclonal
NCBI Full Gene Nameinhibitor of nuclear factor kappa B kinase subunit beta
Research AreaImmunology and Inflammation
IsotypeIgG
Clone2C8
Molecular Weight87

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) HTATSF1 regulates innate antiviral immune response by orchestrating TRAF3-IRF3 and TRAF6-NF-κB pathwaysCell InsightNovember 26, 2025Jia-Qing Zeng, Zi-Lun Ruan, Qi Zhang, Xue-Mei Yi, Yun-Da Chen, Ming-Ming Hu, Shu LiTRAF3 (4729), p-TAK1T184/187 (4508), p-IκBαS32/36 (9246), IκBα (9242), p-IKKα/βS176/177 (2078), IKKβ (2370), and p-p65S536 (3033) (Cell Signaling Technology), HTATSF1 (20805-1-AP) and HECTD3 (11487-1-AP) (Proteintech)

(2) Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosisNature communicationsAugust 9, 2025Hwang CH, Lee M, Kim JW, Nam YW, Hwang G, Ryu HS, Seo J, Lee EW, Ko HW, Song J.Ser 345 (#37333; Cell Signaling), SMURF1 (#sc-100616; Santacruz), USP5 (sc-390943; Santacruz), IKKβ (#2370, Cell Signaling), IκBα (#4814, Cell Signaling), phospho-IκBα (Ser539) (#2859, Cell Signaling), TNFR1

(3) Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptorFrontiers in PharmacologyNovember 14, 2024Weifen Li, Shengnan Mou, Tahir Ali, Tianxiang Li, Yan Liu, Shupeng Li, Xiaoming Yu, Zhi-Jian Yu,Cell Signaling Technology,#8242,1:1000 p-IKK,Cell Signaling Technology,#2694S,1:1000 IKK,Cell Signaling Technology,#2370S,1:1000 Bmal1,Abcam,ab235577,1:1000 p-PKA,Cell Signaling Technology,#9621,1:1000 PKA,Cell Signaling Technology

(4) Anti-Inflammatory Effects and Metabolomic Analysis of Ilex Rotunda Extracted by Supercritical Fluid ExtractionInternational Journal of Molecular SciencesNovember 7, 2024Duc Dat Le, Young Su Jang, Vinhquang Truong, Thientam Dinh, Thinhulinh Dang, Soojung Yu, Mina Leep38 (#9212), p-IKKα/β (#2967), p-IκBα (#9246), p-p65 (#3033), p65 (#8242), IKKα (#2682), and IKKβ (#2370) were procured from Cell Signaling Technology (Danvers, MA, USA). IκBα (SC-371) antibodies were obtained

(5) Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failureFrontiers in ImmunologyNovember 4, 2024Chiara Verra, Maria Kerstin Paulmann, Jamila Wegener, Enrica Marzani, Gustavo Ferreira Alves, Massimo Collino, Sina Maren Coldewey, Christoph ThiemermannRabbit anti-Ser176/180 IKKα/β (Cell Signaling, #2697S), 1:1000 rabbit anti-total IKKβ (Cell Signaling, #2370S), 1:1000 Rabbit anti-NLRP3 (Adipogen, #AG-20B-0014) were used as primary antibodies. On the following

(6) Synthesis and Anti-Liver Fibrosis Research of Aspartic Acid DerivativesMoleculesOctober 9, 2024Miao Lv, Simin Guo, Hexian Yang, Yongjian Wang, Yiming Li, Yang Li, Hong Yi, Hongwei He, Zhuorong LiAbnova (Boulder, CO, USA) and Abcam (Cambridge, UK); anti-GAPDH antibody (#5174), anti-IKKβ antibody (#2370), anti-P-IKKβ antibody (#2697), anti-NF-κB p65 antibody (#8242), anti-P-NF-κB p65 antibody (#3033) and

(7) EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401Cell death and differentiationOctober 1, 2024Nam YW, Shin JH, Kim S, Hwang CH, Lee CS, Hwang G, Kim HR, Roe JS, Song J.12013819001), anti-phospho-IKKα/β (Ser176/180) (Cell signalling, #2682), anti-IKKβ (Cell signalling, #2370), anti-IκBα (Cell signalling, #4814), anti-phospho-IκBα (ser539) (Cell signalling, #2859), anti-phospho-p65

(8) Glucoraphanin and sulforaphane mitigate TNFα-induced Caco-2 monolayers permeabilization and inflammationRedox biologyOctober 1, 2024Zhu W, Cremonini E, Mastaloudis A, Oteiza PI.Human interferon gamma (IFN-γ) and primary antibodies for phospho (Ser176/180)-IKKα/β (#2697), IKKα/β (#2370), phospho (Ser536)-p65 (#3033), p65 (#8242), phospho (Thr202/Tyr204)-ERK1/2 (#4370), ERK1/2 (#9102),

(9) SPARCL1 promotes chondrocytes extracellular matrix degradation and inflammation in osteoarthritis via TNF/NF-κB pathwayJournal of Orthopaedic TranslationMay 28, 2024Yu Miao, Shenghui Wu, Ziling Gong, Yiwei Chen, Feng Xue, Kexin Liu, Jian Zou, Yong Feng, Guangyi Li6956), IKKα (1:1000, Cell Signaling Technology Cat# 2682), IKKβ (1:1000, Cell Signaling Technology Cat# 2370), SPARCL1 (1:1000, Proteintech Cat#13517-1-AP), β-ACTIN (1:1000, Servicebio Cat# GB11001), Goat Anti-Rabbit

(10) Anti-Inflammatory Effects of Idebenone Attenuate LPS-Induced Systemic Inflammatory Diseases by Suppressing NF-κB ActivationAntioxidants (Basel)January 25, 2024Yumin Choi, Young-Lai Cho, Sujeong Park, Minkyung Park, Keun-Seok Hong, Young Jun Park, In-Ah Lee, Su Wol Chung, Heedoo Lee, Seon-Jin LeeUSA); iNOS (13120s), COX-2 (12282s), TNF-α (3707s), IL-1β (12242s), IκBα (4812s), p-IκBα (2859s), IKKβ (2370s), p-IKKβ (2078s), p65 (8242s), p38 (8690s), p-p38 (4511s), JNK (9252s), p-JNK (4668s), ERK (4695s),

(11) Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory responseNatural Products and BioprospectingDecember 1, 2023Tian Lan, Wen Wang, De-Lian Huang, Xi-Xi Zeng, Xiao-Xiao Wang, Jian Wang, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang(#9212), phospho-p38 (#9211), JNK (#3708), phospho-JNK (#4668), ERK (#9102), phospho-ERK (#9101), F4/80 (#2370), CD68 (ab125212), TLR4 (ab9105), MyD88 (ab219413), and TRIF (ab13810) were obtained from Cell Signaling Technology

(12) Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their SurvivalAntioxidants (Basel)August 9, 2023Nejra Cosic-Mujkanovic, Paulina Valadez-Cosmes, Kathrin Maitz, Anna Lueger, Zala N. Mihalic, Marah C. Runtsch, Melanie Kienzl, Michael J. Davies, Christine Y. Chuang, Akos Heinemann, et al.for 15 sec, followed by the addition of 25 µL NP-40, and mixed by vortexing. After centrifugation at 2370× g for 5 min at 4 °C, the cytoplasmic fraction in the supernatant was transferred in a separate epi

(13) miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 SignalingBiomoleculesFebruary 9, 2023Lee H, Kim E, Kim S.following proteins were purchased from the indicated sources: phospho-IKKα/β (2697), IKKα (2682), IKKβ (2370), phospho–NF-κB (3033), NF-κB (8242), phospho-IκB (2859), IκB (4814), phospho-JNK (4668), and K63-linkage

(14) LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleusThe EMBO journalDecember 15, 2022Wu Z, Berlemann LA, Bader V, Sehr DA, Dawin E, Covallero A, Meschede J, Angersbach L, Showkat C, Michaelis JB, et al.,Cell Signaling Technology,"Cat#14127, RRID: AB_2576213" Rabbit polyclonal anti‐IKKβ,Cell Signaling Technology,"Cat#2370, RRID: AB_2122154" Human polyclonal anti‐M1‐ubiquitin (clone 1F11/3F5/Y102L),Genentech,1F11/3F5/Y102L Mouse

(15) Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutationseLifeAugust 30, 2022Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, et al.Flag (F3165; Sigma), IRAK1 (sc-7883; Santa Cruz), phospho-IRAK1 (T209) (A1074; AssaybioTech), IKKβ (2370; Cell Signaling Technology), phospho-IKKα/β (2697; Cell Signaling Technology), p38 MAPK (9212; Cell Signaling Technology

(16) An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammationDisease models & mechanismsJune 1, 2022Díaz de León-Guerrero S, Salazar-León J, Meza-Sosa KF, Valle-Garcia D, Aguilar-León D, Pedraza-Alva G, Pérez-Martínez L.dilution; Cell Signaling Technology, CS-9252); IKKβ (1:1000 dilution; Cell Signaling Technology, CS-2370); NF-κB p65 (1:1000 dilution; Cell Signaling Technology, CS-4764); IRS-1 (1:1000 dilution; Cell Signaling Technology

(17) Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failureCell death & diseaseMay 31, 2022Gehrke N, Wörns MA, Mann A, Hövelmeyer N, Waisman A, Straub BK, Galle PR, Schattenberg JM.(Thr183/Tyr185), XIAP (all Cell Signaling Technology Inc., Cat #2003, 3210, 4927, 9429, 4844, 4272, 2370, 4764, 3033, 9102, 9101, 3493, 53286, 9252, 4668, 2042), GAPDH (EnoGene, New York, NY, USA, Cat #E1C603)

(18) Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrityWorld journal of gastroenterologyDecember 28, 2021Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, et al.phospho-IKKα/β (Ser176/180) (#2697; Cell Signaling Technology, Danvers, MA, United States), IKKβ (#2370; CST), IkBα (#4812; CST), NF-kB p65 (#8242; CST), phospho-NF-kB p65 (Ser536) (#3033; CST), COL-1 (#14695-1-AP;

(19) Self-guarding of MORC3 enables virulence factor-triggered immunityNatureDecember 1, 2021Gaidt MM, Morrow A, Fairgrieve MR, Karr JP, Yosef N, Vance RE.(Cell Signaling, #4302, 1:1000), anti-IRF-7 (Cell Signaling, #4920, 1:1000), anti-IKKβ (2C8) (Cell Signaling, #2370, 1:1000), anti-IKKα (3G12) (Cell Signaling, #11930, 1:1000), anti-MORC3 (NovusBio, NBP1-83036, 1:500),

(20) Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic ReviewInternational journal of molecular sciencesNovember 29, 2021Kurnik-Łucka M, Pasieka P, Łączak P, Wojnarski M, Jurczyk M, Gil K.(55388-1-AP), -Drd5 (20310-1-AP/ADR-005, Proteintech/Alomone); anti-phosphorylated IKKα/β (2697), -IKKβ (2370), -phosphorylated IκBα (9246), -phosphorylated CREB (9198s, Cell Signaling Technology); anti-CREB (48601-2,

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IKKbeta (2C8) Rabbit mAb

IKKbeta (2C8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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IKKbeta (2C8) Rabbit mAb from Cell Signaling Technology

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