Fig 2: Hepatic mRNA expression of genes important in the IKK-NF-kB pathways, inflammation and fibrosis in adult male mice with hepatocyte-specific activation of Ikk2 (Liv-Ikk2ca). a IKK-NF-kB pathways; and b inflammation and fibrosis. N = 6 per group, mean ± SE. *p < 0.05 versus wild-type mice

Fig 3: Hepatic mRNA expression of key antioxidative genes and Nqo1 activities in adult male mice with hepatocyte-specific activation of Ikk2 (Liv-Ikk2ca). a mRNA expression of antioxidative genes; and b Nqo1 activities. N = 6 per group, mean ± SE. *p < 0.05 versus wild-type mice

Fig 4: Hepatic mRNA expression of major cytochome P450s (Cyps) and Phase-II enzymes in adult male mice with hepatocyte-specific activation of Ikk2 (Liv-Ikk2ca). N = 6 per group, mean ± SE. *p < 0.05 versus wild-type mice

Fig 5: Hepatic levels of triglycerides, cholesterol, reduced GSH, endogenous reactive oxygen species (ROS), malondialdehyde (MDA), and hydroxyproline in adult male mice with hepatocyte-specific activation of Ikk2 (Liv-Ikk2ca). a triglycerides and cholesterol; b reduced GSH; c endogenous ROS and MDA; and d hydroxyproline. N = 6 per group, mean ± SE. *p < 0.05 versus wild-type mice