Anti-PREX1 antibodies are used in the immunodetection of the protein phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. In humans, the canonical protein has a reported length of 1659 amino acid residues and a mass of 186.2 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be mainly expressed in peripheral blood leukocytes and brain. PREX1 is known to function as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Synonyms for this target antigen include PIP3 dependent Rac exchange factor 1, ptdIns(3,4,5)-dependent Rac exchanger 1, and phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. PREX1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PREX1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.