PRKDC is a symbol for the gene, Protein kinase, DNA-activated, catalytic polypeptide, in humans. Other names include: DNA-dependent protein kinase catalytic subunit; DNA-PKcs; DNPK1; p460; DNA-PK catalytic subunit; DNAPK; HYRC; HYRC1; IMD26; XRCC7; p350. The encoded protein is an enzyme with an amino acid length of 4128 and a mass of 469.1 kDa. Other isoforms may exist. PRKDC is a member of the PI3/PI4-kinase family. This gene shares homology with other species, including: Mouse, Rat, Zebrafish, Frog, Chicken.