DNA-PKCS (G-4) Antibody sc-5282 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemDNA-PKCS (G-4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-5282
NCBI Gene Aliasesp350, DNAPK, HYRC1, DNA-PKcs, DNAPKc, DNA-PKC, DNPK1, IMD26, HYRC, XRCC7
Antibody TypePrimary Antibodies
Quantity200 µg/ml
ApplicationsWB, IP, IF, ELISA
Reactivityhuman
CloneG-4
FormatPurified
Hostmouse
Conjugate/TagUnconjugated
ClonalityMonoclonal
NCBI Full Gene Nameprotein kinase, DNA-activated, catalytic subunit
TargetDNA-PKCS
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathwaysSci RepOctober 20, 2025Emil Mladenov, Mathias Kallies, Martin Stuschke, Eleni Gkika, George Iliakisfollowing primary antibodies were used: anti-DNA-PKcs (DNA-PKCS antibody (G-4), Santa Cruz Biotechnology, sc-5282), anti-ATM (ATM (D2E2) Rabbit mAb, Cell Signaling, #2873), anti-CtIP (CtIP (D76F7) Rabbit mAb, Cell Signaling

(2) Molecular Insights into Chemotherapy Resistance Mediated by MLL-AF9 Fusion Gene in Pediatric B-Cell Acute Lymphoblastic LeukemiaJournal of Biological ChemistryMay 30, 2025Xu Sang, Yanchun Guan, Mengying Jiang, Xin Chen, Zhen Zhang, Wansheng Peng, Yumeng Wu(500-P234-1MG, Thermo Fisher Scientific), γH2AX (MA1-2022, Thermo Fisher Scientific), and DNA-PKcs (sc-5282, Santa Cruz Biotechnology), were applied to the sections and left to incubate overnight at 4 °C. Following

(3) Armadillo domain of ARID1A directly interacts with DNA-PKcs to couple chromatin remodeling with nonhomologous end joining (NHEJ) pathwayNucleic Acids ResMarch 13, 2025Shin-Ichiro Kanno, Takayasu Kobayashi, Reiko Watanabe, Akihiro Kurimasa, Kozo Tanaka, Akira Yasui, Ayako UiBetyl), anti-FAM98A (Bioss Antibodies, BS-11012R), anti-ERH (sc-373906, Santa Cruz), anti-DNA-PKcs (G-4, sc-5282, Santa Cruz), phospho-DNA-PKcs (Ser2056) (E9J4G, 68716, Cell Signaling Technology), anti-MRE11 (4895S,

(4) Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repairExperimental & molecular medicineFebruary 1, 2025Tao S, Pu Y, Yang EJ, Ren G, Shi C, Chen LJ, Chen L, Shim JS.(sc-6954, Santa Cruz), p-BRCA1 (s1423) (AB600, Beyotime), HSP90 (37-9400, Thermo Fisher), DNA-PKCS (sc-5282, Santa Cruz), pho-DNA-PK (Thr2609) (PA1-29541, Invitrogen), ATR (13934 s, CST). pho-ATR (s428) (2853

(5) Impact of Optimized Ku–DNA Binding Inhibitors on the Cellular and In Vivo DNA Damage ResponseCancers (Basel)September 26, 2024Pamela L. Mendoza-Munoz, Narva Deshwar Kushwaha, Dineshsinha Chauhan, Karim Ben Ali Gacem, Joy E. Garrett, Joseph R. Dynlacht, Jean-Baptiste Charbonnier, Navnath S. Gavande, John J. Turchiprimary antibodies: Phospho-DNA PKcs (S2056) (Cat: ab124918, Abcam, Cambridge, UK), total DNA-PKcs (Cat: sc-5282, Santa Cruz Biotechnology, Dallas, TX, USA), and γ-H2AX pS139 (Cat: 613401, BioLegend, San Diego, CA,

(6) DNA-PK controls Apollo’s access to leading-end telomeresNucleic Acids ResearchMay 8, 2024Ceylan Sonmez, Beatrice Toia, Patrik Eickhoff, Andreea Medeea Matei, Michael El Beyrouthy, Björn Wallner, Max E Douglas, Titia de Lange, Francisca LottersbergerChk2 (BD 611570, BD Biosciences), DCLRE1B/Apollo (HPA064934, Atlas Antibodies), DNA-PKcs (SC-1552, SC-5282, SC-390495 and SC-390849; Santa Cruz Biotechnology), HA (HA.11, #901502 Biolegend), Ku70 (sc-17789 or

(7) DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65Biochemistry and biophysics reportsSeptember 1, 2023Hasegawa Y, Asada S.BSA/TBS-T at room temperature for 1 h and treated with a primary antibody DNA-PKcs (1/200 dilution) (sc-5282, Santa Cruz Biotechnology), Ku70 (1/200 dilution) (sc-17789, Santa Cruz Biotechnology), Ku80 (1/200

(8) RUNX3 regulates the susceptibility against EGFR-targeted non-small cell lung cancer therapy using (47)Sc-conjugated cetuximabBMC cancerJuly 12, 2023Kim DM, Lee SY, Lim JC, Cho EH, Park UJ.Cell Signaling Technology (Danvers, MA, USA). Antibodies targeting p53 (Cat# sc-126), DNA-PKcs (Cat# sc-5282), Ku70 (Cat# sc-5309), and p27 (Cat# sc-1641) were obtained from Santa Cruz Biotechnology (Dallas, TX,

(9) ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockadeNature communicationsJuly 10, 2023Liu X, Cen X, Wu R, Chen Z, Xie Y, Wang F, Shan B, Zeng L, Zhou J, Xie B, et al.China). The antibodies were provided as follows: DNA-PKcs (#ET1610-12, 1: 2000, HUABIO), DNA-PKcs (#sc-5282, 1:200, Santa Cruz Biotechnology), TBK1 (#3504, 1: 1000, Cell Signaling Technology), p-TBK1 (Ser172)

(10) HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppressionCell reportsMarch 28, 2023Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA.

(11) Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaksNAR cancerMarch 1, 2023Mendoza-Munoz PL, Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Dynlacht JR, Garrett JE, Turchi JJ.(S2056) (Cat: ab124918, Abcam), phospho-DNA PKcs (T2609) (Cat: ab4194, Abcam), total DNA-PKcs (Cat: sc-5282, Santa Cruz Biotechnology), γ-H2AX pS139 (Cat: 613401, BioLegend), phospho-ATM (Ser1981) (Cat: ab81292,

(12) NTF4 plays a dual role in breast cancer in mammary tumorigenesis and metastatic progressionInternational journal of biological sciencesJanuary 1, 2023Sun R, He J, Xiang Q, Feng Y, Gong Y, Ning Y, Deng C, Sun K, Zhang M, Cheng Z, et al.Cell Signaling Technology), N-cadherin (#13116, Cell Signaling Technology) and PRKDC (#12311, Cell Signaling Technology; sc-5282, Santa Cruz), ANXA1 (sc-12740, Santa Cruz), and then incubated with Alexa Fluor® 594 and 488 (Invitrogen

(13) Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell CarcinomaMolecular cancer therapeuticsSeptember 6, 2022Castellano GM, Zeeshan S, Garbuzenko OB, Sabaawy HE, Malhotra J, Minko T, Pine SR.were anti-GAPDH (Millipore #MAB374), anti-Vinculin (Santa Cruz SC-73614), anti-DNA-PKcs (Santa Cruz SC-5282), anti-P-S2056-DNA-PKcs (Abcam ab18192), anti-AKT1 (Cell Signaling Technology (CST) #2938), anti-P-S473-AKT

(14) ARID1A-deficient cells require HDAC6 for progression of endometrial carcinomaMolecular oncologyJune 1, 2022Megino-Luque C, Sisó P, Mota-Martorell N, Navaridas R, de la Rosa I, Urdanibia I, Albertí-Valls M, Santacana M, Pinyol M, Bonifaci N, et al.2111); anti‐HDAC6 (CellSignaling, 7612); anti‐Ku70 (Santa Cruz, sc‐17789) and anti‐XRCC4 (Santa Cruz, sc‐5282); anti‐p‐ATM (S1981) (Abcam, ab208775); anti‐ATM (Santa Cruz, sc‐135663); anti‐Phospho‐ATR (Ser428)

(15) Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joiningNucleic acids researchMay 6, 2022Cabello-Lobato MJ, Jenner M, Cisneros-Aguirre M, Brüninghoff K, Sandy Z, da Costa IC, Jowitt TA, Loch CM, Jackson SP, Wu Q, et al.(ab33499, Abcam, 1:500 or Bethyl A300-730A, 1:1000), anti-LIG4 (ab193353, Abcam, 1:1000), anti-DNA-PKcs (sc-5282, Santa Cruz, 1:100), anti-GST (27457701V, G&E, 1:1000), anti-6×His tag (MA1-21315, Invitrogen, 1:1000),

(16) Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasisNature communicationsFebruary 3, 2022Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, Lee YJ, Yuan X, Ellis L, Di Vizio D, et al.anti-MKK7 (Santa Cruz Biotechnology #sc-25288) at 1:100, and mouse anti-PRKDC (Santa Cruz Biotechnology #sc-5282) at 1:100. Imaging was performed with an All-in-one fluorescence microscope (BZ-X700, Keyence) under

(17) The Botanical Drug PBI-05204, a Supercritical CO(2) Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human GlioblastomaFrontiers in pharmacologyJanuary 1, 2022Colapietro A, Yang P, Rossetti A, Mancini A, Vitale F, Chakraborty S, Martellucci S, Marampon F, Mattei V, Gravina GL, et al.

(18) Assessing kinetics and recruitment of DNA repair factors using high content screensCell reportsDecember 28, 2021Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, et al.anti-RNF168 (Millipore # ABE367) 1:1000; anti-53BP1(BD Bioscience # 612522) 1:1000; anti-DNAPK (Santa Cruz # sc-5282) 1:1000; anti-CHK1 (Cell Signaling # 2360S) 1:1000; anti-CHK2 (Millipore # 05–649) 1:1000; anti-β-ACTIN

(19) Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast CancerCancer researchDecember 15, 2021Gou X, Anurag M, Lei JT, Kim BJ, Singh P, Seker S, Fandino D, Han A, Rehman S, Hu J, et al.N-terminal ERα (Millipore; cat #04-820, RRID:AB_1587018) or DNA-PKcs (Santa Cruz Biotechnology; cat #sc-5282, RRID:AB_2172848) antibodies with ECL-based signal detection on a Bio-Rad Imaging System. Statistical

(20) ZBTB38 suppresses prostate cancer cell proliferation and migration via directly promoting DKK1 expressionCell death & diseaseOctober 25, 2021Ding G, Lu W, Zhang Q, Li K, Zhou H, Wang F, Zhao C, Fan C, Wang J.follows: anti-ZBTB38 antibody (21906-1-AP, Proteintech), anti-DKK1 (21112-1-AP, Proteintech), anti-PRKDC (SC-5282, Santa Cruz), anti-HA (51064-2-AP, Proteintech), anti-FLAG (20543-1-AP, Proteintech), anti-GAPDH (10494-1-AP,

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DNA-PKCS (G-4) Antibody

DNA-PKCS (G-4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

Citations (86)

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DNA-PKCS (G-4) Antibody from Santa Cruz Biotechnology, Inc.

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