Anti-SPPL2B antibodies are used in the immunodetection of the protein signal peptide peptidase like 2B. In humans, the canonical protein has a reported length of 592 amino acid residues and a mass of 64.6 kDa. Its subcellular localization is in the Golgi, lysosomes, and cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in adrenal cortex and mammary gland. It is a member of the Peptidase A22B protein family. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include intramembrane protease 4, presenilin homologous protein 4, presenilin-like protein 1, and SPP-like 2B. SPPL2B gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is a widely used application for the SPPL2B antibodies listed below. In addition, ELISA is also a common application.