Anti-CD1D antibodies are used in the immunodetection of the protein CD1d molecule. In humans, the canonical protein has a reported length of 335 amino acid residues and a mass of 37.7 kDa. Its subcellular localization is in the ER, lysosomes, and cell membrane. It is noted to be expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. CD1D is reported to be an antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Post-translational modifications have been described, including glycosylation.
The CD1D marker can be used to identify Superficial Zone B Cells.* Synonyms for this target antigen include R3, R3G1, antigen-presenting glycoprotein CD1d, CD1D antigen, d polypeptide, HMC class I antigen-like glycoprotein CD1D, and CD1A. CD1D gene orthologs have been reported in the mouse, rat and chimpanzee species. Over 50 citations in the literature describe the use of CD1d antibodies in research. Western Blot is a widely used application for these antibodies. Flow Cytometry and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4