Anti-CD169 antibodies are used in antigen-specific immunodetection in biological samples. The target CD169 is a known alias name of the protein sialic acid binding Ig like lectin 1, encoded by the SIGLEC1 gene in humans. This 1709-amino acid residue protein is known to be involved in cell adhesion and cell matrix adhesion, among other biological processes. It is localized to the cell membrane and is secreted of the cell and features glycosylated post-translational modifications. In terms of tissue expression, it is noted to be expressed by macrophages in various tissues. The CD169 marker has been identified in populations of Alveolar Macrophages CCL3+ Cells, Alveolar Macrophages, Alveolar Macrophages Proliferating Cells, Alveolar Macrophages Mt+ Cells, and Interstitial Macrophages.* The term SN is another synonym for CD169.
*HuBMAP Human Reference Atlas v1.4