Editorial Articles

Comprehensive overviews of enabling tools and techniques, as well as trends, researched and written by Biocompare writers.

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Next Generation Sequencing 2013: Looking Into Genomes
January 29, 2013
Next Gen Sequencing firms continue to optimize their hardware, software, and reagents to squeeze ever more bases from their instruments ever more ... read more
Western Blotting Continues to Evolve
February 04, 2013
Though Western blotting has for years been an important mainstay for protein researchers, many believe it has yet to reach its full potential. ... read more
The Art and Science of Cell Line Development
February 05, 2013
The traditional means of making a cell line is to partially transform a cell or to start with a cancer in which transformation has already occurred ... read more
Extraction of RNA from Archived FFPE Samples
February 07, 2013
The benefits of using FFPE samples often outweigh this downsidse. You can extract and purify the RNA, and use it for expression profiling with ... read more
Chromatin Immunoprecipitation Methods Move Toward Easier Automation and Increased Sensitivity
February 12, 2013
Chromatin immunoprecipitation (ChIP) is an immunoprecipitation process to identify specific stretches of chromosomal DNA associated with a protein of ... read more
Protein Expression In Vitro: Cell-free Systems
February 13, 2013
A multitude of applications can be performed using a cell-free, in vitro protein-expression system. Applications include genetic verification and ... read more
State of the Art: miRNA Tools
February 14, 2013
To start with, microRNAs (miRNAs) are short (20-¬¬ to 23-nucleotide) eukaryotic, noncoding regulatory RNAs that are enzymatically generated from ... read more
What Should I Consider Before Buying an Automated Liquid Handler?
February 15, 2013
The automated liquid handler—built to precisely move liquids from one vessel to another in applications ranging from nucleic-acid purification and DNA... read more
Happy Birthday To You – PCR is 30 years old
February 19, 2013
Since PCR’s invention in the 1980s by chemist Kary Mullis at the Cetus Corporation, our ability to amplify specific DNA fragments is often taken for ... read more
What's Going on in There? See It All With Live Cell Imaging
February 22, 2013
We want to elucidate the dynamic events that go on inside cells. What are proteins doing and what are their interactions? With live-cell imaging, ... read more
Mining Genetic Variation: The Latest SNP Analysis Tools
February 27, 2013
As their name suggests, single nucleotide polymorphisms (SNPs) are single-base sites of variation between peoples’ genomes, and they are, by far, the ... read more
Cells Detected, Alive or Dead
March 01, 2013
Most cell-viability assays work according to the general principle of making live and dead cells easily distinguishable from each other so they can be... read more
New Possibilities in Research with the Latest High Content Screening Systems
March 05, 2013
High-content screening (HCS) systems are essentially high-speed automated microscopes with associated automated image analysis and storage ... read more
Cold Storage: A Buyer’s Guide
March 08, 2013
Cold storage for labs typically includes refrigerators, general-purpose freezers and ultra-low temperature freezers. In all cases, it is crucial for ... read more
Exome Sequencing Comes of Age
March 12, 2013
In effect, exome sequencing is just a special form of targeted sequencing, an application in which researchers capture specific genomic segments for ... read more
Metabolomics: Sifting Through Complex Samples
March 14, 2013
Metabolomics seeks to catalog and quantify all the metabolites in a living organism. There are probably between 2,500 and 5,000 small molecules in the... read more