Fast and Efficient Bacterial Lysis Reagent

Stanford University
Department of Pathology
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

ThermoScientific

Product Name:

B-PER™ Complete Bacterial Protein Extraction Reagent

Catalog Number:

89821

I study gene signaling pathways and use bacterial expression systems for protein production. B-PER provides a simple and fast way to lyse bacterial pellets and consistently improves protein recovery.

Experimental Design and Results Summary

Application

Bacterial cell lysis for protein extraction

Starting Material

Bacterial cell pellets

Tips

Depending on the application, protease inhibitors, reducing agents, and chelating agents may be added to the reagent.

Results Summary

I used the reagent at 4ml/mg of bacterial pellet. The reagent efficiently lysed in 30-60 min and improved protein yield compared with mechanical lysis approaches. It was compatible with downstream purification workflow.

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Summary

The Good

Multiple samples can be lysed in less than hour

The Bad

Expensive

The Bottom Line

A very convenient and effective bacterial lysis reagent when protein yield and ease of use are priorities

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