Brilliance Beyond Limits: A Clear, Bright Dye for Super-Resolution Imaging

The Scripps Research Institute
Immunology Microbiology
Postdoctoral Researcher

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Company:

Abberior

Product Name:

Abberior LIVE RED STED dye

Catalog Number:

LVRED

In my research, I investigate how bacterial cells construct and modify their outer layer. I utilized a specific dye to label particular protein-SnapTag fusions, which I then imaged using STED super-resolution microscopy. The objective was to observe the locations of these protein fusions with high precision at various stages of the cell cycle. The dye enabled us to visualize these differences clearly.

Experimental Design and Results Summary

Application

I used the dye for live-cell labeling followed by STED super-resolution imaging.

Starting Material

Exponentially-grown bacterial cells

Tips

Do not freeze-thaw the dye frequently.

Results Summary

The SnapTag fusion showed clear labeling at the cell surface. Using STED microscopy, the resolution of the signal was greatly improved. This allowed us to visualize certain patterns of this protein during various cell cycle stages and also after certain cell wall-acting antibiotics treatment.

DOI or PMID #

N/A

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Summary

The Good

Very bright and photostable signal and works well with STED depletion laser.

The Bad

I see background labelling.

The Bottom Line

A powerful and reliable red dye for anyone who needs clear, and high-resolution live-cell images.

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