VDAC Antibody for Mitochondrial Loading Control From Abcam

Department of Pathology
Stanford University
Postdoctoral Researcher

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Company:

Abcam

Product Name:

Recombinant Anti-VDAC1/Porin + VDAC2 antibody [EPR10852(B)]

Catalog Number:

ab154856

Clone Number:

N/A

To study mitochondrial proteins and their activity, I isolated mitochondria from cells. To check the purity of mitochondria and the efficiency of the mitochondria preparation protocol, I used the VDAC antibody as a control.

Experimental Design and Results Summary

Applications

Western blot

Sample

Neuro2a cells

Primary Incubation

1:10000 in 1% BSA, Overnight at 4°C

Blocking Agent

5% BSA in Tris-buffered Saline Tween-20

Secondary Incubation

1:10000 HRP-conjugated anti-Rabbit IgG, 1 hour at RT

Tertiary Incubation

N/A

Detection

ECL detection in documentation system (Vilber Lourmat).

Results Summary

The antibody gives a clean band for VDAC in total cell fraction and mitochondrial fraction. It is absent from the cytosolic fraction.

DOI or PMID #

N/A

Additional Notes

Aliquot and freeze for longer storage.

Related Categories

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Summary

The Good

Works in higher dilutions, and gives a good and clean signal.

The Bad

None.

The Bottom Line

A good mitochondrial loading control.

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