Di-tert-butyl dicarbonate for Boc Protection

M.D. Anderson

Overall

Quality of Results

Ease-of-Optimization

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Company:

Sigma Aldrich

Product Name:

Di-tert-butyl dicarbonate

Catalog Number:

205249

The aim was to protect just one side of a diamine to be subsequently able to link it to a second scaffold.

Experimental Design and Results Summary

Application

Boc protection

Starting Material

2,2-dimethylpropano-1,3-diamine

Tips

Keep in mind that it can be toxic, flammable, and corrosive

Results Summary

Using 1 equivalents of Boc anhydride and 3 equivalents of the diamine, after an overnight reaction at room temperature, I was able to get the product with 90% yield.

DOI or PMID #

N/A

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Summary

The Good

Not too expensive, easy to use and works well.

The Bad

Must be stored at 4 °C.

The Bottom Line

Works well and is not too expensive. To anyone who needs to work on Boc protection, I would recommend it.

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