Trifluoroacetic Acid From Thermo Scientific For Boc Deprotection

M.D. Anderson

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
Write a Review

Company:

Thermo Scientific

Product Name:

Trifluoroacetic acid

Catalog Number:

A12198.22

Info: Supplier Page 

We need to deprotect a Boc amine to be able then to link it to a carboxylic acid and form a new peptide bond.

Experimental Design and Results Summary

Application

Boc deprotection

Starting Material

N/A

Tips

Keep in mind that it is corrosive and volatile.

Results Summary

The mixture was composed of a solution DCM:TFA (30% TFA) and 5mL of DCM. It works well, since I have a quantitative yield, and really fast (takes just 30 minutes).

DOI or PMID #

N/A

Image Gallery

Summary

The Good

Accessible, works perfectly and fast.

The Bad

Corrosive and volatile so, needs to be handled carefully.

The Bottom Line

Cheap product that is easily accessible. Absolutely highly recommended.

Join the discussion