Effective Reducing Agent From Sigma Aldrich

M.D. Anderson

Overall

Quality of Results

Ease-of-Optimization

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Company:

Sigma Aldrich

Product Name:

Diisobutylaluminium hydride (1M)

Catalog Number:

256811

This product was used to reduce ester to aldehydes avoiding the risk of getting the corresponding alcohol.

Experimental Design and Results Summary

Application

Reduction of esters

Starting Material

Esters

Tips

Corrosive, explosive and toxic hence take necessary precautions.

Results Summary

DIBAL-H helped me to get the aldehyde of my starting material, without passing by the oxidation of the corresponding alcohol.1.2 equivalents, at -78 °C for 30 minutes are enough to get the desired product.

DOI or PMID #

N/A

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Summary

The Good

Works fast.

The Bad

Needs a temperature of -78 °C, and storage temperature at -6 °C, and is also toxic.

The Bottom Line

I recommend it for anyone who needs to get an aldehyde instead of passing by the oxidation of an alcohol

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