Synthesizing New Peptide Bond with Acryloyl Chloride

M.D. Anderson

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Company:

MilliporeSigma

Product Name:

Acryloyl chloride

Catalog Number:

A24109

Synthesis of new peptide bond starting from acyl chloride and an amine. I used 1 equivalent added at 0 °C and then brought to room temperature and left, under stirring, for 1h.Inert atmosphere and solvent needed to increase the yield of the reaction.

Experimental Design and Results Summary

Application

Synthesis of new compound with a peptide bond.

Starting Material

N/A

Tips

Really reactive

Results Summary

I used it to form a new bond between this acyl chloride and an amine. Since it can polymerize, is important to control the reactions condition. I worked at 0 °C in inert atmosphere of N2.

DOI or PMID #

N/A

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Summary

The Good

Super reactive.

The Bad

Polymerize drawbacks, stinging smell.

The Bottom Line

Not too expensive, react well but you have to control the reactions conditions. I'll buy it again.

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