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PE/Cyanine7 anti-human CD130 (gp130) Antibody
362007
2E1B02
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Antibodies are produced by plasma cells (PC) that are terminally differentiated B cells and play crucial roles in host protection against infections but are considered to mediate autoimmunity in patients with rheumatic diseases, such as systemic lupus (SLE) or rheumatoid arthritis (RA). Our research aims at understanding the biology of B cells and antibody-secreting cells (ASC) in health and disease, in this experiment, we are looking for markers of PC.
Flow Cytometry
Isolated PBMCs from HD peripheral blood
surface staining with CD130 PE-Cy7, 20 min at 4C
Fc block
N/A
Flow cytometer
In this work, we were looking for surface markers that are differentially expressed by B cells (CD19+) and plasma cells (PC). We found that CD130 is higher expressed by PC in comparison with B cells (CD20-).
35464469
It works.
It not very bright.
Can be used.