Good Marker for Naive T Cells

Chemical/Biomedical Engineering
University of Toronto
PhD Candidate

Overall

Quality of Results

Ease-of-Optimization

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Company:

BioLegend

Product Name:

CD62L BV421

Catalog Number:

104436

Clone Number:

MEL-14

Info:Supplier Page View Product Specs

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We use single cell analysis methods to study the mechanisms responsible for establishing and maintaining immune tolerance.

Experimental Design and Results Summary

Applications

Flow cytometry

Sample

Mouse spleen, lymph nodes

Primary Incubation

Block: 1:50 in 100uL at 37C for 30 min

Blocking Agent

Fc Block (aCD16/32)

Secondary Incubation

L/D: Zombie NIR 1:4000 in 100 uL at RT for 20 min

Tertiary Incubation

Surface stain: 1:200 in 100uL at 4C for 30 min

Detection

Spectral flow cytometry (Cytek Aurora)

Results Summary

Good separation of naive T cells from activated T cells after pre-gating on CD3+ cells to remove non-T cells. Can also be used to further distinguish between central memory and effector memory cells with other markers. Very strong staining with minimal optimization needed for spectral flow cytometry.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Very strong signal, low non-specific staining.

The Bad

Not available in many other colors.

The Bottom Line

A great antibody for studying T cell subsets.

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