Antibody for Detecting 5HT Neurons

Neuroscience
UAB
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Sigma

Product Name:

Anti-Tryptophan hydroxylase 2 Antibody

Catalog Number:

ABN60

Clone Number:

I have used this antibody to detect 5HT neurons in the brain. It has worked very well in sample of rat and mouse.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Mouse brain

Primary Incubation

Incubation was done with Ab diluted to 1:1,000 for 16h at 4ºC

Blocking Agent

BSA 4% in PBS

Secondary Incubation

Incubation was done with 2nd Ab diluted to 1:1,000 for 1h at room temperature

Tertiary Incubation

None

Detection

Fluorescence (AF 488)

Results Summary

In all cases reactivity is quite good at 1:1,000 dilution. This protein is detected only in 5HT-neurons and thus can be used to differentiate these neutron from the other cells from the brainstem

DOI or PMID #

Additional Notes

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Summary

The Good

Reliable and sensible

The Bad

I have experienced no issues with this product

The Bottom Line

Great antibody to detect 5HT neurons in the brain

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