Dim CD3 Antibody

Pathology
UMass
Lab Technician

Overall

Quality of Results

Ease-of-Optimization

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Company:

Beckman Coulter

Product Name:

CD3-PB, UCHT1, 0.5 mL, ASR

Catalog Number:

A93687

Clone Number:

UCHT1

Info: Supplier Page View Product Specs

Browse Similar Products: CD3 Antibodies

CD3 is the archetypic marker for identification of T cells. We needed a good CD3 antibody on the violet laser to stain T cells with high quality.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Human WBC prep

Primary Incubation

10uL for 15 min at Room Temp

Blocking Agent

None

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

Navios 10-Color Flow Cytometer

Results Summary

The results were acceptable, showing decent separation of CD3+ vs. CD3- cells; however, the staining was dim. As shown in the picture, the Median Fluorescence Intensity (MFI) is quite low for the positive cells. This is OK in most cases, but ideally the resolution should be better. Brighter violet dyes are available, and so my advice is to use a different antibody.

DOI or PMID #

Additional Notes

Related Categories

Image Gallery

Summary

The Good

Easy to optimize

The Bad

Dim signal

The Bottom Line

A decent antibody, but not recommended when a strong signal is needed. Other violet dyes will produce stronger signals. Check other suppliers before you buy.

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