RIPA Buffer Worked Well for Us

Medical University of Graz
Biophysics
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Thermo Fisher Scientific

Product Name:

RIPA Lysis and Extraction Buffer

Catalog Number:

89900

Cells grown to 80% confluency in 35-mm cell culture dishes are washed with 1×PBS and lysed in ice-cold 100 μl RIPA buffer containing 1 μl protease inhibitor cocktail. Supernatant from cell lysates is used for protein estimation, gel electrophoresis, and western blotting.

Experimental Design and Results Summary

Application

Protein extraction from cultured cells.

Starting Material

Cultured cells.

Tips

Incubate cells in RIPA buffer on ice with gentle shaking for uniform lysis and protein extraction.

Results Summary

The protein lysate was subjected to gel electrophoresis and western blotting to detect the expression of specific proteins.

DOI or PMID #

N/A

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Summary

The Good

Easy and ready to use buffer for extraction of cytoplasmic, membrane and nuclear proteins.

The Bad

It is not suitable for co-immunoprecipitation.

The Bottom Line

Efficient buffer for extraction of cellular proteins.

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