Crystal Violet Solution for Colony Formation Assays

Heidelberg University
Biochemistry
Graduate Student

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Company:

Merck (Sigma-Aldrich)

Product Name:

Crystal violet solution 1% aqueous solution

Catalog Number:

V5265-500ML

Crystal violet solution was used to stain Hela cells colonies after 15 days of treatment with DMSO and inhibitory drug.

Experimental Design and Results Summary

Application

Colony formation assay

Starting Material

Hela cells, 6 well plates, crystal violet, water and methanol

Tips

Crystal violet is a very toxic and known cancerogenic solution. Discard the wastes with attention!

Results Summary

100 cells/well of Hela cells were plates in a 6 well plate and growth for 15 days while treatment with DMSO (c-) and drug.Cells were washed with PBS 1x and fixated (10 minutes) with MeOH before staining with crystal violet 0,5%

DOI or PMID #

N/A

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Summary

The Good

Very fast staining of Hela cells and U2OS colonies (max 3 hours)

The Bad

Toxic

The Bottom Line

The product works very well.

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