BD Biosciences
PE Rat Anti-Mouse CD43
561857
S7
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Antibodies are produced by plasma cells (PC) that are terminally differentiated B cells and play crucial roles in host protection against infections but are considered to mediate autoimmunity in patients with rheumatic diseases, such as systemic lupus (SLE) or rheumatoid arthritis (RA). Our research aims at understanding the biology of antibody-secreting cells (ASC) and B cells in health and disease. Here, we aimed at staining CD43 in spleen and BM.
Flow Cytometry
Spleen and bone marrow from C57BL/6
Surface staining with CD43 PE (1/200), 20 min at 4C
Fc block (2.4G2 clone)
N/A
Flow cytometer
CD43 is not expressed by naive mature B cells that are the majority of the B cells in the spleen. And is expressed by almost all other leukocytes that differentially express it, e.g. T cells as it can be seen in the figure.
Works well