Nice Antibody for LC3A (Specific) from CST

Cell Biology
Harvard Medical School
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Cell Signaling Technology

Product Name:

LC3A

Catalog Number:

4599

I work on selective forms of autophagy, especially focusing on ribophagy and ER-phagy. I have used large numbers of antibodies for proteins related to autophagy. This LC3A antibody is the second antibody i tried. This one works well.

Experimental Design and Results Summary

Applications

Western Blot

Sample

HCT116 cells stably expressing GFP-LC3A

Primary Incubation

1:1000 dilution in 5% BSA, TBST

Blocking Agent

5% non-fat milk in TBST

Secondary Incubation

1:20000 IRdye800 rabbit

Tertiary Incubation

Washed three times

Detection

Odyssey Clx

Results Summary

I tried an antibody from Abgent and it did not work in my hand. As a substitute, i ordered this antibody and it worked well. As indicated in the figure, it is quite selective for LC3A even though there's a 90% sequence homology with LC3B.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Selectivity

The Bad

Nothing

The Bottom Line

Good for LC3A selectivity probing.

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