Anti-Connexin43 Antibody Works Well for Chemiluminescence

Biological Science
Florida State University
Graduate Student

Overall

Quality of Results

Ease-of-Optimization

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Company:

Invitrogen (Life Technologies)

Product Name:

Rabbit anti-Connexin43 (phosphorylated)

Catalog Number:

48-3000

I wanted to investigate whether the target proteins had any diurnal variations in olfactory bulb tissue and investigate whether these proteins varied between biological replicates and over the course of a day.  Here, I wanted to examine connexin43 phosphorylation levels via immunoblot in brain tissue.  This antibody worked well for chemiluminescence reactions and showed up quickly.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Brain tissue homogenate

Primary Incubation

1:1000 overnight at 4 degrees C

Blocking Agent

5% milk in TBS (0.1% Tween-20)

Secondary Incubation

1:10,000 for 90 minutes at room temperature

Tertiary Incubation

NA

Detection

Chemiluminescence

Results Summary

Bands showed up at the correct weight quickly. Though the bands were not as crisp as they could have been, they were at the correct spot and less intense than the staining for total Cx43 (on the left).

Additional Notes

None

Related Categories

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Summary

The Good

Worked well the first time with minimal fuss.

The Bad

May only work for immunoblot and not IHC or IP.

The Bottom Line

If you need a phospho-Cx43 antibody for immunoblotting, this one works well.

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